Downsizing - I've owned multiple bags over the years from a large 54L eBag Weekender Mother Lode with multiple compartments, down to my current single compartment Patagonia Arbor 20L bag. This bag might not be for everyone but I would advise if you take anything away from this site, it's getting your current bag down a few liters. Two major things I like about the Arbor 20L is the full front loading zip which allows access to everything at once and it's one dedicated compartment which doesn't sacrifice any space with unneeded dividers and organizers.
The key to all of this is to keep your packing list to the bare essentials. I also expect to have my laundry run every 4-5 days which cuts down on the amount I need to bring with me. The other great thing about this bag is that unpacking takes seconds and then it's time to hit the city as it doubles as my city day and hiking bag.
5x Under shirts
1x Denim Jeans
Compactable Rain Coat
Tooth brush, tooth paste, floss
You're able to see everything that is packed at a glance
The front loading zipper folds down to assist in packing
Finished packing with room to spare